If you recently installed or updated iTunes, you may also need to run iTunes at least once and agree to Apple's terms before running iExplorer. In some cases, restarting your computer is also needed.
If you are getting an error on your Mac about how
iExplorer cannot be opened because of a problem (crash on launch)
If iExplorer is still crashing on your Mac or PC, it's going to be due to an issue separate from iTunes or OSXFUSE, so please be sure to submit a crash report (and include your email on it) and fill out a support ticket to notify us that you've submitted one.